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dihydroergotamine, ergotamine, ergoloid mesylates, methysergide, or ergot-type medication - do not take within 24 hours of taking sumatriptan
feverfew
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate - do not take sumatriptan within 2 weeks of stopping MAOI therapy
other migraine medicines like almotriptan, eletriptan, naratriptan, rizatriptan, zolmitriptan - do not take within 24 hours of taking sumatriptan
tryptophan

Imitrex may also interact with the following medications:

lithium
medicines for mental depression, anxiety or mood problems
medicines for weight loss such as dexfenfluramine, dextroamphetamine, fenfluramine, or sibutramine
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